Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis

The claudin multigene family is associated with various aberrant physiological and cellular signaling pathways. However, the association of claudins survival prognosis, pathways, diagnostic efficacy in colon cancer remains poorly understood. Methods: Through effective utilization bioinformatics methods, including differential gene expression analysis, set enrichment analysis protein-protein interaction (PPI) network single sample (ssGSEA), mutational variance identifying receiver operating characteristic curve Cancer Genome Atlas adenocarcinoma (COAD). Results: We found that: CLDN2, CLDN1, CLDN14, CLDN16, CLDN18, CLDN9, CLDN12, CLDN6 are elevated COAD. In contrast, CLDN8, CLDN23, CLDN5, CLDN11, CLDN7, CLDN15 downregulated By analyzing public datasets GSE15781 GSE50760 from NCBI-GEO ( https://www.ncbi.nlm.nih.gov/geo/ ), we have confirmed that CLDN14 significantly upregulated CLDN8 CLDN23 normal colon, tumor, liver metastasis tissues human samples. Various mutated to be Conclusion: immune regulation, pathway regulations, diagnosis These findings may provide new molecular insight into treatment cancer.